Duchenne Muscular Dystrophy (DMD) is a sex-linked characteristic encoded by the dystrophin gene found on the X chromosome. A mutation of the dystrophin gene causes issues in the structural support of muscle tissue. This disease affects 1 in 3,600 boys, resulting in muscle degeneration and eventual death. Paul has DMD and was fortunate to live to have children. He married Lisa at age 20, and they had two children, one normal boy and one diseased girl, before Paul passed away at age 25.
a. What are the genotypes and phenotypes of Paul and Lisa?
i. Given these data, would you expect Lisaâs family pedigree to show the presence of absence of DMD? Why or why not?
b. What are the genotypes and phenotypes of their children?
i. Given these data, should the son or daughter be most concerned about transmittance to offspring? Why?
Duchenne Muscular Dystrophy (DMD) is a sex-linked characteristic encoded by the dystrophin gene found on the X chromosome. A mutation of the dystrophin gene causes issues in the structural support of muscle tissue. This disease affects 1 in 3,600 boys, resulting in muscle degeneration and eventual death. Paul has DMD and was fortunate to live to have children. He married Lisa at age 20, and they had two children, one normal boy and one diseased girl, before Paul passed away at age 25.
a. What are the genotypes and phenotypes of Paul and Lisa?
i. Given these data, would you expect Lisaâs family pedigree to show the presence of absence of DMD? Why or why not?
b. What are the genotypes and phenotypes of their children?
i. Given these data, should the son or daughter be most concerned about transmittance to offspring? Why?
