Question

1. Part of sequence of template DNA strand is 3'ATA5'. How manydifferent mutations can result from a single base substitution inthe sequence? Classify them based on protein syntheized if they aresilent, missense, or nonsense.

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2. In theory, deamination of both cytosine and 5-methylcytosineresults in a mutation. However, nucleotide substitutions producedby loss of the amino group from cytosine are rarely observed,although those produced by loss of the amino group from5-methylcytosine are relatively frequent. What is a possibleexplanation for this phenomenon?