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Botulinus toxin causes paralysis. It binds to presynaptic sitesat the motor end plate (neuromuscular junction) and prevents theexocytotic release of transmitter from vesicles. Predict theconsequences (increase, decrease, no change & explain why) ofblocking the release of acetylcholine at the neuromuscular junctionon the following: 1. Presynaptic resting potential 2. Presynapticaction potential amplitude 3. Presynaptic Ca2+ influx 4.Presynaptic transmitter release 5. Postsynaptic resting potential6. Postsynaptic end plate potential 7. Postsynaptic actionpotential amplitude 8. Postsynaptic action potential frequency 9.Muscle contractile strength
Botulinus toxin causes paralysis. It binds to presynaptic sitesat the motor end plate (neuromuscular junction) and prevents theexocytotic release of transmitter from vesicles. Predict theconsequences (increase, decrease, no change & explain why) ofblocking the release of acetylcholine at the neuromuscular junctionon the following: 1. Presynaptic resting potential 2. Presynapticaction potential amplitude 3. Presynaptic Ca2+ influx 4.Presynaptic transmitter release 5. Postsynaptic resting potential6. Postsynaptic end plate potential 7. Postsynaptic actionpotential amplitude 8. Postsynaptic action potential frequency 9.Muscle contractile strength
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Deanna HettingerLv2
28 Sep 2019