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  • How dopost-transcriptional and post-translational mutations affect thefinal products?
  • Which mutationshave a greater impact on the final product?
  • How does theredundancy of the genetic code protect the end products whenmutations do occur

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Tod Thiel
Tod ThielLv2
28 Sep 2019

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Related questions

1) Can you compare/contrast Importin and Exportin? (and how does Ran affect each of those?)

2) What determines whether a protein will be translated in the cytosol or on the ER surface?

3) What is the difference between post-translational ER import and co-translational translocation?

1)Explain Motoo Kimura’s contribution to our understanding of population evolution. What is “neutral evolution”? How do you know that a population is in mutation-drift equilibrium at a locus? Why do we care about evolution in genetic regions that don’t code for protein product?

2)Use language to explain what the Wright-Fisher model (the equation 1/2Ne ) is “saying”. Be able to use the equation to explicitly demonstrate how genetic drift may occur under different circumstances.

3)Use language to explain what the Moran model (the equation Var (pt+1) = 2p1q1/2N) is “saying”. Be able to use the equation to explicitly demonstrate how genetic drift may occur under different circumstances.

4)What is a “selectively neutral locus”? When mutations occur in the genome, do regions which are selectively neutral accumulate mutations which persist in the population at the same rate, when compared to loci under selection? Why or why not?

5)Why don’t all organisms exhibit identical neutral mutation rates? Why doesn’t every region of the genome exhibit identical neutral mutation rates? What is a mutational “hotspot”, and what type of DNA sequence might be found there?

3. Complementary base pairing is an essential feature of DNA replication and transcription and translation. Explain how.

4. What’s the significance of the fact that operator and promoter overlap?

5. In which direction (3’?5’ or 5’?3’) does elongation of RNA occur?

6. In the genetic code, UUU and UUC both code for the same amino acid. What is this amino acid and what does this indicate about the genetic code?

7. Which part of a ribosome accepts a tRNA molecule that is attached to a growing polypeptide chain?

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