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28 Sep 2019
Ok, so in class we are talking about how mouse derivedantibodies cannot be theraputically used in humans because they areforeign. Instead, we can use recombinant DNA to produce an antibodythat contains the V region from a mouse and the C region from ahuman. He says that this hybrid antibody is still immunogenicbecause of the mouse V region, but not as much as an antibody thatis entirely mouse derived.
My question is, if our immune systems are capable of mounting aresponse to variable regions on Ab, how do we not produce immuneresponses to our own variable regions. Are all our antibodiestolerated against all the endless combinations of our otherantibodies...That seems unlikely? How does this work?
Ok, so in class we are talking about how mouse derivedantibodies cannot be theraputically used in humans because they areforeign. Instead, we can use recombinant DNA to produce an antibodythat contains the V region from a mouse and the C region from ahuman. He says that this hybrid antibody is still immunogenicbecause of the mouse V region, but not as much as an antibody thatis entirely mouse derived.
My question is, if our immune systems are capable of mounting aresponse to variable regions on Ab, how do we not produce immuneresponses to our own variable regions. Are all our antibodiestolerated against all the endless combinations of our otherantibodies...That seems unlikely? How does this work?
Jarrod RobelLv2
28 Sep 2019
