. Carlos and Sophia have brought their child Maria to your hospital. She has lower than normal blood O2 levels and other symptoms of à thalassemia, although those symptoms are not as severe as many cases of this disease. A Northern blot was done on the mRNA from Maria using a probe that binds to the third exon of the à globin gene. The Northern blot showed a band of normal size and density. Mariaâs parents are of Hispanic (Mediterranean) origin, and they do not know if they may be distantly related.
a. Give one hypothesis for what Mariaâs genotype might be that explains her symptoms and also the Northern blot results.
b. Design a test or tests that would prove that your hypothesis in a is correct.
c. What results would you expect from this test or tests if your hypothesis is correct?
d. Explain to Carlos and Sophia (who are not scientists) how the results of your test(s) confirm your hypothesis.
. Carlos and Sophia have brought their child Maria to your hospital. She has lower than normal blood O2 levels and other symptoms of à thalassemia, although those symptoms are not as severe as many cases of this disease. A Northern blot was done on the mRNA from Maria using a probe that binds to the third exon of the à globin gene. The Northern blot showed a band of normal size and density. Mariaâs parents are of Hispanic (Mediterranean) origin, and they do not know if they may be distantly related.
a. Give one hypothesis for what Mariaâs genotype might be that explains her symptoms and also the Northern blot results.
b. Design a test or tests that would prove that your hypothesis in a is correct.
c. What results would you expect from this test or tests if your hypothesis is correct?
d. Explain to Carlos and Sophia (who are not scientists) how the results of your test(s) confirm your hypothesis.
