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1) Predict the impact of a hydroxyproline -> proline mutationon collagen's structure and function. Justify your answer.

2) Predict the impact of a hydroxylysine -> lysine mutationon collagen's structure and function. Justify your answer.

3) Which mutation (Q1 or Q2) describes the change(s) occuring inscurvy? Explain.

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Tod Thiel
Tod ThielLv2
28 Sep 2019

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Related questions

For Q1-3, predict the impact of each point mutation onhemoglobin's structure and function. Be specific and detailed inyour answer. You will need to refer to the globin figures in thepowerpoint slides to answer these questions:

1) Proximal histidine (H93) -> Ala

2) Distal histidine (H64) -> Phe

3) Phe (found deep in the heme binding pocket) -> Thr

4) List the interactions that stablize the R-state(oxyhemoglobin).

PART C IS THE PART I NEED HELP WITH PLEASE

Below is a partial mRNA sequence. Use it to answer the following questions.

5' - GCCGAUCGAACU - 3'

What is the correct reading frame for this mRNA?

5' - G | CCG | AUC | GAA | CU - 3'

If a single base-pair deletion occurred in the part of the gene that corresponds to the mRNA above and the resulting partial amino acid sequence was (N-term-...P-M-N...-C-term), which new partial mRNA sequence would be consistent with this change?

5' - G | CCG | AUG | AAC | U - 3'

Part C

The amino acids in the original partial sequence (N-term-...P-I-E...-C-term) have little to no impact on protein structure and function. However the amino acid sequence near the C-terminal end of the protein is required for normal function. Any amino acid changes in this region of the protein will result in a nonfunctional protein.

Given this information, which reversion mutation in the gene would restore the normal function of the protein?

Select all that apply.

Insertion of 2 base-pairs in the region of the proline codon

Deletion of 5 base-pairs in the region of the proline codon

Deletion of 2 base-pairs in the region of the proline codon

Deletion of 1 base-pair in the region of the proline codon

Insertion of 1 base-pair in the region of the proline codon

Insertion of 4 base-pairs in the region of the proline codon

1. predict the direction of water movement based on differences in solute concentrations. Use the terms osmotic pressure, hypotonic, isotonic, and hypertonic
2. Why do membranes have to be selectively permeable?

3. What determines whether a particular substance can diffuse (simple or facilitated) through a membrane?

4. What mechanisms drive molecules across membranes? Use the terms concentration gradient, (facilitated) diffusion and active transport.
5. Which parts of the plasma membrane proteins do you expect to be hydrophobic or hydrophilic? Justify your answer.
concise and short answers pls

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