Question

II. Take the following theoretical biochemical pathway (eacharrow represents an enzyme and therefore a gene):

A -> B -> C -> D ->->-> E

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V V V

F G H

Normal metabolism of the amino acid is from A to E, with otherpathways possible as depicted. However, a number of mutations havebeen discovered in the pathways from A to E that can lead todisease conditions. For example, an excess of G leads to hair loss,an excess of F leads to hearing loss, an excess of A leads toslurred speech, an excess of C leads to obesity, and an excess of Hleads to high blood pressure.

Where is/are the mutations that would result in a person havingobesity and hair loss?

Where is/are the mutations that would result in a person havinghearing loss only?

Where is/are the mutations that would result in a person slurredspeech and hearing loss?

Is it possible for someone to have obesity and high bloodpressure in this model above (explain why or why not indetail)?

Could a person have mild forms of all of these symptoms at thesame time? If so (or not), explain why