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20 Apr 2019

If a child is born with an insufficient amount of growth hormone, he or she will develop dwarfism. Do you think that such a child should be given supplemental growth hormone? What are the physical and ethical issues involved?​​

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Irving Heathcote
Irving HeathcoteLv2
22 Apr 2019

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Related questions

Genetics question on genetic dwarfism:

Seven months pregnant, an expectant mother was undergoing a routine ultrasound. While prior tests had been normal, this one showed that the limbs of the fetus were unusually short. The doctor suspected that the baby might have a genetic form of dwarfism called achondroplasia. He told her that the disorder was due to an autosomal dominant mutation and occurred with a frequency of about 1 in 25,000 births. The expectant mother had studied genetics in college and immediately raised several questions. How would you answer them?

1. How could her baby have a dominantly inherited disorder if there was no history of this condition on either side of the family?

2. Is the mutation more likely to have come from the mother or the father?

3. If this child has achondroplasia, is there an increased chance that their next child would also have this disorder?

4. Could this disorder have been caused by X rays or ultrasounds she had earlier in pregnancy?

Thank you!

A.Phenylketonuria is a human disease caused by a recessive allele (p). Normal individuals have at least one dominant allele (P). If 2 cousins who are heterzygotes marry, perdict the percentage (%) of their children with each of the following genotypes or phenotypes:

1. Homozygous dominant

2. Carriers like their parents

3. Children with phenylketonuria

B. For any one child born to these parents, what is the chance that she/he will be totally normal?

Annette's maternal grandfather died of Huntington's disease when he was 53 and Annette was 8. Huntington's is a rare autosomal dominant degenerative neural disorder that usually hits people in their late forties, early fifties. Annette loved her grandfather very much and was deeply affected by the painful progression of his disease. She wants to get pregnant but does not want to risk giving birth to a child that will suffer as much as her grandfather. If she tested positive for Huntington's, what is the probability of her first child to develop Huntington's? Of her second child? Of her mother? (Note that since Huntington’s is so rare, you can assume that neither grandmother, nor father or partner have the Huntington’s mutation).

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