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28 Jul 2019

What kinase phosphorylates serine 2 of the repeat sequence in the C-terminal domain of the largest subunit of RNA polymerase II?

Select one:

a. cycT

b. cdk2

c. cdk7

d. cdk9

e. cycH

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Keith Leannon
Keith LeannonLv2
29 Jul 2019

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Related questions

TFIIH plays 2 separate roles in the initiation of transcription. What are they? (Choose 2 answers, 1/2 mark each)

Select one or more:

a. cdk7, a component of TFIIH, phosphorylates Ser5 of the CTD of RNA polymerase II.

b. it is involved in 3' end cleavage.

c. It phosphorylates Ser2 of the CTD of RNA polymerase II.

d. helicases in the complex unwind DNA in the promoter

e. TFIIH is a sequence specific transcription factor.

RNA processing is determined by phosphorylation patterns in the C-terminal repeat domain (CTD) of the RNA polymerase II. Explain in a mechanistic manner how a deficiency in the enzyme CTDK-1 affects RNA processing.

RNA polymerase II from eukaryotes has a carboxyl-terminal domainthat is subject to phosphorylation by kinases in the cell. Twoprominent modifications are to serine 2 and serine 5. Serine 5peaks at the 5’ end of genes and serine 2 peaks at the 3’ ends ofgenes. You’ve identified a kinase from cells that you suspectmodifies serine 2. You use a molecular technique called RNAi todeplete this kinase from cells. Do you think this would affecttranscription initiation or capping? When you analyze the RNAsproduced from the cells depleted of the kinase (accept that you cando this), you notice that the lengths of the RNAs in the depletedcells are abnormally long and have defects in polyadenylation.Why?

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