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14 Apr 2019

Phenylketonuria(PKU) is a disease that results from a recessive gene. Suppose that two unaffected parents produce a child with PKU.

a) What is the probability that a sperm from the father will contain the PKU allele?

b) What is the probability that an egg from the mother will contain the PKU allele?

c) What is the probability that their next child will have PKU?

d) What is the probability that their their next child will be heterozygous for the PKU gene?

Please go in detail. Thank you.

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Related questions

In humans there is a disease called Phenylketonuria (PKU)which is caused by a recessive allele. People with this allele have a defective enzyme and cannot break down the amino acid phenylalanine. This disease can result in mental retardation or death. Let “E” represent the normal enzyme. Also in humans in a condition called galactose intolerance or galactosemia, which is also caused by a recessive allele. Let “G” represent the normal allele for galactose digestion. In both diseases, normal dominates over recessive. If two adults were heterozygous for both traits (EeGg), what are the chances of having a child that is completely normal? Has just PKU? Has just galactosemia? Has both diseases?

1) PKU is an inherited disorder that is caused by two recessive alleles. A couple who plan to have children are concerned because the wife is known to be heterozygous for the gene. The husband is homozygous dominant. What percent of their children are likely to have the PKU problem and need to be placed on a special diet? Show a Punnett square to defend your answer.

2) Huntington's Chorea is a lethal genetic disease of the nervous system caused by a single dominant allele. After a couple has a child, they dis­cover that the husband has Huntington's Chorea. There is no history of the disease in the wife's family. What chance is there that their child will be afflicted? Show a Punnett square to defend your answer.

Sandra and Steven are expecting their first child. Each have one female sibling who is affected with PKU (Phenylketonurea) and no other family history of the disorder is known on either side. They ask what their risk is of having an affected child. What do you tell them? A) They must both be heterozygotes so their risk of having an affected child is 25%.

B) There is a 50% chance they are heterozygous carriers so they should get genetic testing.

C) Since neither one of them is affected, they are not at risk of having an affected child.

D) You can't give them any firm answers because you don't know their genotypes.

E) Since this disorder is an autosomal recessive no one in the next generation will have the disease.

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