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15 Apr 2018
The binding of O2 to hemoglobin is pH sensitive; this is called the Bohr effect. A decrease in pH lowers the affinity of hemoglobin for O2. A highly metabolizing tissue, such as a working muscle, generates a lot of CO2. Using your knowledge of the reactions that take place between CO2 and water (write out the equilibria!), explain why the Bohr effect promotes more efficient O2 delivery to working muscles.
The binding of O2 to hemoglobin is pH sensitive; this is called the Bohr effect. A decrease in pH lowers the affinity of hemoglobin for O2. A highly metabolizing tissue, such as a working muscle, generates a lot of CO2. Using your knowledge of the reactions that take place between CO2 and water (write out the equilibria!), explain why the Bohr effect promotes more efficient O2 delivery to working muscles.
Bunny GreenfelderLv2
17 Apr 2018
