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What would be the effect of the following on glycolysis, fermentation, citric acid cycle, oxidative phosphorylation, reduction of oxygen, transport of molecules across inner mitochondrial membrane and so forth?

A loss of function mutation in pyruvate dehydrogenase

A block in step 7 of glycolysis

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Hubert Koch
Hubert KochLv2
4 Jun 2019

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Related questions

Which of the following accurately describe difference(s) between oxidative phosphorylation and substrate-level phosphorylation during aerobic respiration in eukaryotes?

a.

Oxidative phosphorylation relies on energy initially derived from redox reactions to power ATP synthase, and substrate-level phosphorylation relies on enzymatic reactions to phosphorylate ADP.
b.

Oxidative phosphorylation takes place in the inner mitochondrial membrane and substrate-level phosphorylation only occurs in the cytosol.
c.

Oxidative phosphorylation uses oxygen as a substrate and substrate-level phosphorylation uses phosphate.
d.

Oxidative phosphorylation takes place during glycolysis and the electron transport chain and substrate-level phosphorylation occurs during the citric acid cycle and chemiosmosis.
e.

Oxidative phosphorylation produces less ATP than substrate-level phosphorylation.

what is the effect of Warburg effect on:
a) Glycolysis
b) conversion of pyruvate to lactate
c) pentose phosphate pathway
d) oxidative phosphorylation in the mitochondria
e) citric acid cycle
Also provide reasons for them.

1. Which enzyme of the citric acid cycle catalyzes a substrate-level phosphorylation reaction?

A. Isocitrate dehydrogenase

B. Succinyl-CoA synthetase

C. Fumarase

D. Aconitase

E. Citrate synthase

2. Which enzyme of the citric acid cycle is embedded in the mitochondrial inner membrane

A. Fumurase

B. Malate dehydrogenase

C. Isocitrate dehydrogenase

D. Succinate dehydrogenase

E. Aconitase

3. The addition of Isocitrate will stimulate the TCA cycle. How many ATP can you produce from one molecule of Isocitrate?

A. 10

B. 7.5

C. 4

D. 5

4. In the reaction mechanism for the oxidative decarboxylation of pyruvate, which cofactor is required for the decarboxylation step?

A. Thiamine pyrophosphate

B. Lipoic acid

C. FAD

D. NAD+

E. all of the above

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