What are the two main gene types involved in the development of cancer? Explain with examples
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Describe how mutations within the Wnt signaling pathway can lead to the development of colon cancer. Which gene products involved in this pathway are most often mutated in cancer, and in what way(s) are they mutated?
Phosphoglycerate dehydrogenase is involved in the synthesis of Ser. The level of this enzyme is very high in some cancer types thus causing an increase on Ser in these cancer cells. Cancer cells with increased Ser show an increase in flux through the TCA cycle. Explain.