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Pyruvate kinase is subject to allosteric regulation. i) Describe the metabolic importance of regulating flux through the pyruvate kinase reaction. [5] ii) Explain the advantage of activating pyruvate kinase with fructose-1,6-bisphosphate. [5]
1. Describe the allosteric regulation and the covalent modification (phosphorylation/dephosphorylation, if available!) of the following enzymes: a) Phosphofructokinase-1. b) Phosphofructokinase 2/Fructose-phosphatase 2 c) Hexokinase. d) Pyruvate kinase. e) Glycogen phosphorylase. f) Glycogen synthase. g) Pyruvate carboxylase and PEP carboxykinase.
Describe the allosteric regulation model for transcription termination and briefly indicate how this model can explain both Rho dependent and Rho independent termination reactions.
