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14 Aug 2019

What is the FORMAT of a FULL manuscript? I did a research paper for my biology seminar course and we currently submitted our first draft of our research paper. However, now we have to write a full manuscript, and I am not sure how to format it because we were not given any guidelines, examples, etc. I am not even sure where to begin in writing this manuscript. For my research paper I used 5-6 sources, for the manuscript am I incorporating all sources? How would I do this? I just need a FORMAT/OUTLINE of what to write and how to section the paper. How is a manuscript for a research paper formatted?? Please help!

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Keith LeannonLv2

15 Aug 2019

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PURPOSE: To examine the genetic, Biochemical, and Cell biological mechanisms of disease development.

In class we have focused on many of the fundamental principals and techniques of genetics and molecular biology. For this assignment I want you to see how these ideas are applied in studying genetic diseases. In addition, I want you to get insight into the experimental design and procedures that are used for expanding our understanding of genetics and how they are applied to studying and treating human genetic diseases.

The goal will be a final research paper that will be due by the last day of class (April 3, 2016). An outline of what is expected to be presented in the paper is listed below.

Paper Guidelines: Review of a Specific Disease

Components:

A. Clinical Features of the Disease

ï· Age of onset
ï· Male/ Female predominance
ï· Clinical symptoms and pathology ï· Population distribution

B. Genetics/ Transmission

ï· Spontaneous/ Inherited
ï· Inheritance distribution
ï· Identification/ isolation of gene/ loci ï· Mutation of gene

C. Molecular Pathology

ï· Effect of mutation on structure/ function of protein
ï· What/ how pathways are affected
ï· Effect on development/ function of cells, tissue, and organs ï· How gene(s) is related to clinical manifestations
ï· Animal models

Please note that all of the information may not be available or understood for your disease. I expect each of the sections to be addressed in the paper (A., B., & C.), however the subtopics (identified by bullet points) may not be understood. I would like the paper as complete as possible, however the final content will be determined by what is currently known about the disease.

You will accomplish this in three steps. A description of each step and the due date are presented below.

1) Choosing a disease.
Due Date: Sunday March 13, 2016

I want you to identify a human genetic disease and provide a very brief overview of the disease (Section A). I want you state how the disease is inherited (Autosomal dominant, Autosomal recessive,

etc) a brief description of the clinical features and the gene that is mutated (if known). This assignment should be no more than 2 pages and is worth 50 points towards your final grade.

2) Identify an experimental journal article. Due Date: Sunday March 20, 2016

I want you to identify a published research journal article that examines the genetic disease that you have chosen. The paper must have been published within the last two years. The paper must present experimental evidence that is relevant to your disease. I want you to submit the paper to me as well as write a one page summary of what was learned by the research study and how it applies to the understanding of the molecular pathology of the disease (Section C.). You can search for a journal article using the resources of the library. I would also like you to choose one experiment (figure) in the paper and describe what experimental techniques were used for that part of the study. This section should not exceed 1 page. This is worth 50 points towards your grade.

3) Final Paper.
Due date Sunday April 3, 2016.

Your final paper will address all of the sections presented in the outline above. This will be a combination of steps 1) & 2), however more detail will be expected for each of the three sections than is presented in the first two assignments. You will be expected to use at least three (you will likely find more than three) references and have them properly referenced in your paper. I want the paper organized as presented in the outline. The final paper should not exceed 6 pages (not including references). The final paper is worth 200 points towards your final grade.

aquamarinealligator170

PURPOSE: To examine the genetic, Biochemical, and Cell biological mechanisms of disease development.

The goal will be a final research paper that will be due by the last day of class (April 3, 2016). An outline of what is expected to be presented in the paper is listed below.

Paper Guidelines: Review of a Specific Disease

Components:

A. Clinical Features of the Disease

ï· Age of onset
ï· Male/ Female predominance
ï· Clinical symptoms and pathology ï· Population distribution

B. Genetics/ Transmission

ï· Spontaneous/ Inherited
ï· Inheritance distribution
ï· Identification/ isolation of gene/ loci ï· Mutation of gene

C. Molecular Pathology

You will accomplish this in three steps. A description of each step and the due date are presented below.

1) Choosing a disease.
Due Date: Sunday March 13, 2016

I want you to identify a human genetic disease and provide a very brief overview of the disease (Section A). I want you state how the disease is inherited (Autosomal dominant, Autosomal recessive,

etc) a brief description of the clinical features and the gene that is mutated (if known). This assignment should be no more than 2 pages and is worth 50 points towards your final grade.

2) Identify an experimental journal article. Due Date: Sunday March 20, 2016

fuchsiacricket487

Water and Minerals

COLLAPSE

This discussion requires knowledge of the material from the chapter and research from online databases or valid research sources. This is truly an excellent learning experience for all of us.

Cancer and Chronic Disease (parkinson's, alzeimers, MS, CVD, auto-immune etc) are words that scare most of us. Certainly when it comes to prevention research shows that smoking, excessive alcohol use, exposure to toxins, obesity, poor diet, lowered immunity, inflammation are all implicators. We can definitely reduce our risk with good lifestyle choices (not smoking, normal BMI, etc.) and that includes dietary choices. There is quite a bit of research and debate about which minerals are beneficial for cancer and/or disease prevention (if at all) and research changes often. You can also focus on water, this will probably lead you down a track to discussing the effects of certain pollutants in the water supply. In any case we are going to find that research and share the knowledge!

This week, for your original posting, find a scholarly based article, professional journal article, original research from grey literature (www.greylit.org) or well respected organization/association research on diet and cancer or chronic disease prevention. This could include the presence of minerals, as supplements or from food, or something related to the water supply and cancer/chronic disease prevention, special diet for cancer/chronic diseases prevention etc. It can be specific to a particular type of disease or cancer or more general. If you select a chronic disease, select one specific one. We are on the minerals chapter, so I would like to see research focused on a mineral or that includes a mineral or multiple minerals. (for example though, don't research a high protein diet as that is a macronutrient).

What to consider:

1. Two wasy to navigate sources for you: get on Google scholar: https://scholar.google.com or for non-published research you can query: www.greylit.org OR have the MC librarian direct you to the various databases you have access too (you can call MC library and they will help you if you are fully online and don't want to go in). Absolutley NO wikipedia, livestrong or webmd, Mayo type sites. You can start here for topic ideas but look further! We are looking for scholarly research. Professional organizations are also a good place as well (for instance, I am interested in digestive conditions, and utilize the American Gastroenterological Association site which links to their journal).

2. find something you are interested in and use that as the basis of your search. This could be information from chapter 8. Also remember, it does not just have to be cancer, you can select any chronic condition you are interested in and see if there is research related to vitamins, minerals or phytochemicals.

3. **In many cases on Google Scholar you can see several version of an article and often you can access a free PDF version of the full article. If NOT, call the MC library and ask for our college log on and see if we have rights to the article. They may have given this info to you but I have found most students have to ask. OR the MC library will actually retrieve the full text article for you and email you the PDF, utilize the librarians!! They love it. **do NOT pay to purchase a full text article online! Utilize the MC library!!

3. If you find an article of interest in a regular magazine or paper (print or online) like Health magazine online, New York times, Wall street journal etc. and you like it, then at the END of the article or referenced IN the article will be information on the original research where the writer got the information. You can discuss the general article in your research but also find the original scholarly article online! **include both in your original posting as attachments or links.

For your original posting:

1. in the Subject box put the topic you researched i.e. lead contaminated water and the effects of cognitive development

2. Then post your article (and include either a link or preferabley the pdf or word doc so we can see the entire article). and also provide a detailed summary of the information you read about and if you agree or disagree with the information. Also discuss why you selected this particular article. **document the source appropriately, I am not concerned if you use APA or MLA.

3.**IMPORTANT, for full points YOU are summarizing what the article/research study said in your own words and discussing merits, issues, if you agree, disagree etc. I am having you attach the article/research study you referenced instead of just a works cited info so others in the class can access the information as well. **you are not cutting and pasting the abstract!!