Summarize the main mechanisms of tumor escape from immune surveillance.
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a. Describe the main elements of the process through which the immune system distinguishes self from nonself.
b. How is the surveillance of the tissues carried out?
c. What is reponsible for this surveillance?
d. What does the term foreign mean in reference to the immune system?
Cancer is the result of the escape from the MHC-peptide/TCR surveillance system. Give an example.
Describe the mechanism of Chronic Myeloid Leukemia using: ABL-BCR, translocation, phosphorylation, cell division, constitutively active, immune surveillance, apoptosis, blast crisis.