CMB 311 Study Guide - Quiz Guide: Dna Polymerase Iii Holoenzyme, Dna Mismatch Repair, Dna Polymerase I
Document Summary
Yes all organisms have the ability to repair dna damage. Dna recombination: involves exchange of genetic material between multiple chromosomes or different regions of the same chromosome. Base insertion can involve single or multiple bases. Base deletion can involve single or multiple bases. Mmr is used to repair mismatches caused by replication errors. Muts, muth, mutl recognizes and binds to the mismatch. Exonuclease i excises a stretch of unmethylated strand. Dna pol iii fills in gaps created by exonuclease i. Chemical modifications of dna that can alter base pairing properties (errors in replication) Can be lethal if cell is not repaired, can cause cancer. Yes dna deamination and base methylation both can cause mutations. Base methylation - causes damage so that base pairs no longer match up, mistake is replicated and therefore there is a mutation. Ber repairs damages that does not distort the dna double helix.
