BIOCHEMISTRY Lecture Notes - Lecture 1: Pentose Phosphate Pathway, Keto Acid, Pyruvate Dehydrogenase Complex

• School: Kerala University of Health Sciences - KUHS
• Department: Biochemistry
• Course: BIOCHEMISTRY

Document Summary

Cereals (whole wheat flour and unpolished handpound rice) are rich sources of thiamine. When the grains are polished, aleurone layer is usually removed. Pyruvate dehydrogenase: the coenzyme form is thiamine pyrophosphate (tpp). It is used in oxidative decarboxylation of alpha keto acids, e. g. pyruvate decarboxylase, a component of the pyruvate dehydrogenase complex. It catalyzes the breakdown of pyruvate, to acetyl-coa, and carbon dioxide. Alpha ketoglutarate dehydrogenase: an analogous biochemical reaction that requires tpp is the oxidative decarboxylation of alpha ketoglutarate to succinyl coa and co2. Transketolase in the hexose mono-phosphate shunt pathway of glucose. The main role of thiamine (tpp) is in carbohydrate metabolism. So, the requirement of thiamine is increased along with higher intake of carbohydrates: deficiency manifestations of thiamine. Edema of legs, face, and serous cavities are the main features. Dry beriberi: in this condition, cns manifestations are the major features. Peripheral neuritis with sensory disturbance leads to complete paralysis.