B PHARMACY Lecture 4: Urinary Tract Infection

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Definition: symptomatic presence of microorganism within urinary tract (,kidneys. Is a common infection that usually occurs when bacteria enter the opening of the urethra and multiply in the urinary tract. A uti can manifest as several syndromes associated with an inflammatory response to microbial invasion that range from asymptomatic bacteriuria to pyelonephritis. Classification &aetiology: Degree: o 1-uncomplicated occur in individuals who lack structural or functional abnormalities in the ut that interfere with the normal flow of urine. Mostly in healthy females of childbearing age 2-complicated predisposing lesion of the. Ut such as congenital abnormality or distortion of the ut, a stone a catheter, prostatic hypertrophy, obstruction, or neurological deficit all can interfere with the normal flow of urine and urinary tract defences. Recurrent utis >3 symptomatic until within 12 months following clinical therapy. Multiple symptomatic infections with asymptomatic periods reinfection: caused by a different organism than originally isolated and account for the majority of recurrent utis.

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