CHEM 451 Lecture Notes - Lecture 10: Rossmann Fold, Triosephosphate Isomerase, Alpha Helix
Document Summary
Em structure of human y assembly thing - 2 arms and tail. Tail makes protein protein interactions with other parts of nuclear pore ring. Purple, pink = alpha solenoids, makes protein protein interactions with y complex. Has to shuttle between cytoplasm and nucleus where it binds to y protein, in cytoplasm it binds to mrna (regulatory role and involved in transport into nuclear pore of other proteins) Complex where you have 2 alpha solenoids and a beta propeller. Beta strands pack against each other in parallel form in interior, alpha helices flank around the beta strands ___ Rossman fold = 2 pairs of beta strands, alpha helices on outside, often a nucleic acids protein, at the ends of proteins there are loop regions that are important for specificity. Tim barrel named after triosephosphate isomerase, lots of enzymes have this structural motif.
