CHEM 451 Lecture Notes - Lecture 8: Rna Recognition Motif, Rossmann Fold, Sh3 Domain
Document Summary
Turn, but just single alpha helix/ beta sheet/ Fold is made up of number of diff motifs. Motif = repeating unit of super secondary structures, shows up in many different proteins (hence repeating), not it"s an arrangement helix-turn-helix, sheet-turn-sheet. Supersecondary is because it"s multiple elements of secondary structures, can be helix turn loop, more than one secondary structure. Domains = self folding, has function associated with it, not talking about secondary structures. Fold and domain overlap as you describe fold of domain, all the elements that come together to form domain. Domain are like modules (eg. 3 pdz domains, organisms with same may have 2 or 4 pdz due to evolving differently depending on needs) Each domain has separate function and they contribute to function of protein. Idps is a catalytic pair, product of reactions is substrate for enzyme next to it, so they couple nicely, form product immediately.
