BIO SCI 93 Lecture Notes - Lecture 9: Paracrine Signalling, Fc Receptor, Cell Signaling

• School: UC-Irvine
• Department: Biological Sciences
• Course: BIO SCI 93
• Professor: WOOD, M., GREEN, K., BUSCIGLIO, J

Document Summary

3 stages of cell signaling: reception, signaling molecule binds to receptor on the plasma membrane, 4 types of signals. Secreted signals that act at distant sites: hormones, travel to target cells at distant sites, animal cells: travel in circulatory system (blood stream, plants: travel through vessels, cell to cell, or diffusion in the air. Intracellular signals: through the gap junctions and cell junctions, transduction, signal travels through relay molecules, response, activation of cellular response. Induces change in location/ shape of the receptor. Receptors: (a ligand is a molecule that binds to a larger molecule) 30% of all proteins encoded by the human genome are cell surface receptors. More than 1000 gpcr"s have been characterized. Tyrosine: specific type of amino acid that can receive phosphate groups. Can activate multiple cellular response (different than g proteins) Kinases are enzymes that catalyze the transfer of phosphate groups.