BIO 111 Lecture Notes - Lecture 11: Atherosclerosis, High-Density Lipoprotein, Blood Vessel

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4 Aug 2020
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When the body starts to run out of fuel from food, it turns to body stores. Fatty acids are used for energy by many organs: typical fuel mix at rest is 50/50 carbohydrate/lipid for liver and muscle. Anytime fat is broken down for energy, carbohydrates must be available otherwise ketones form. High ldl cholesterol increases risk of heart disease. Diet high in sat and trans fat and low in veggies/fruits and whole grains. 75-80% of our cholesterol is synthesized in the body. Sat and trans fat triggers body to produce cholesterol. Dietary cholesterol plays a lesser role than sat or trans fat in cardiovascular disease. ~60% exhibit litter increased blood cholesterol with a high cholesterol diet. Starts with soft fatty streak than enlarge and harden to form plaques. Narrows passage of arteries and makes them inelastic. Mounds of lipid material mixed with smooth muscle cells and calcium. Atherosclerosis develops through a complex inflammatory response to tissue damage:

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