BIO 361 Lecture Notes - Lecture 22: Allosteric Regulation, Hexokinase, John Wiley & Sons
10 Jul 2016
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Document Summary
G6p gets rearranged via the enzyme phosphoglucose isomerase to fructose-6-phosphate (f6p). The rationale for the reaction involves the independent modulation of 6-phosphates. It is an isomerization reaction that occurs because the reactants are hemiacetals and hemiketals. Focus on species of cis-enediolate intermediate, which is an intermediate dehydrogenated to move the double bond of the carbonyl from the 1- to the 2-position. hydrogenated and. When moved to the 2-position, we can synthesize f6p from g6p (creation of electrophilic carbonyl on the 2-position to allow ring closure through intramolecular attack). *note bis- and di- prefix denote the same thing. A phospho- group is on both the 1- and 6-carbon of fructose. We are phosphorylating 2 alcohols, because the carbonyl is being moved from the 1- to the 2- position as we converted glucose to fructose. This is part of the rationale for why we isomerize glucose to fructose. The reactions of glucose to fbp are not all highly reversible.
