BIO 361 Lecture Notes - Lecture 23: Phosphodiester Bond, Hemiacetal, Phosphorolysis
10 Jul 2016
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The first phosphorylation is to trap glucose in the cell (glucose -> g6p). The pentose pathway is important for not only making dna and rna but for creating intermediates and. Nadph (reducing reagent). (review) pfk is under considerable allosteric regulation. V-type allosteric enzymes have allosteric effectors that regulate the catalytic activity of enzymes, while k-type allosteric enzymes, like hemoglobin, modulate the affinity of enzymes for substrates. Amp, an allosteric activator of pfk, is a product of the breakdown of atp when atp is used to phosphorylate various metabolic intermediates. Therefore, in the presence of amp, the affinity of pfk for its substrates increases. Because amp is acting as positive allosteric effector at 1/10th concentration at which. Although amp is present at lower concentrations in cells, the enzymes that use amp as a positive allosteric effector turn on. The products of pfk are two catabolites dihydroxyacetone phosphate (dhap) and glyceraldehyde-3-
