BIO 361 Lecture Notes - Lecture 31: Ubiquitin, Chymotrypsin, Trypsin

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They"re broken down to supply amino acids for energy when carbs are scarce. Usually occurs in lysosomes (nonselective) or in cytosol by ubiquitin-proteasome pathway. Pepsin cuts protein into peptides in stomach. Trypsin and chymotrypsin cut proteins and large peptides into smaller peptides in the small intestine. Aminopeptidase and carboxypeptidases a and b degrade peptides into amino acids in the small intestine. Break down many types of biomolecules (peptides, nucleic acids, lipids, and carbs) Digest food, organelles, and whole cells phagocytosis. Can fuse with other vesicles, organelles, or structures. Ub is conjugated to proteins with 3 enzymes. Has 2 pockets: 1 for ub and the other for the protein. >600 e3 (divided in 4 major classes) E3 can only recognize a small subset of proteins. Composed of 4 stacked rings ( / / / ) symmetric. Subunits unwind the proteins in an atp dependent reaction to feed them into the proteasome for degradation.

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