BIOL 0280 Lecture Notes - Lecture 14: Urea Cycle, Chymotrypsin, Trypsin

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Aas released from protein breakdown are not needed for protein synthesis. Protein rich diet --> aa excess, which cannot be stored. In poorly-controlled diabetes or starvation, proteins broken down to provide energy when sugars unavailable (via aa catabolism) Aas bound for catabolism are mostly used as c source for tca cycle. Proteases and hydrolases in gi tract break down dietary proteins --> uptake of aas. Pepsin: cuts protein into peptides in the stomach. Trypsin and chymotrypsin: cut proteins and larger peptides into smaller peptides in the small intestine. Aminopeptidase and carboxypeptidases a, b: degrade peptides into aas in the smaller intestine. Lots of reactions that deal with aaa directly are in the liver. Glutamine (one extra amino group to be taken out) --> a- ketoglutarate. *glutamate is absorbing the ammonia from the aas. Passive diffusion from epithelial cells, active transport via gills. Rather insoluble, excretion as paste allows the animals to conserve water.

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