EEOB 2520 Lecture Notes - Lecture 11: Macrophage, Axon, Myelin
29 Apr 2016
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Decrease activation: ligand messenger --> catabolize it (destroy it, receptor: lower its affinity (mismatching its shape and charge) and lower saturation / hide receptors, for membrane bound receptor- do endocytosis, don"t need to destroy them. Hide behind two membranes means the ligand can"t get to it because it is polar: intracellular receptor- catabolism- can"t hide them because the ligand is nonpolar and can go through all membranes. These have more than one stop in their pathway therefore we can go after anyone in the path because it"ll all decrease the receptor activation. 2nd or 3rd messenger inactivate (only for membrane bound messengers not intracellular messengers because they don"t have more than one messenger in pathway) Increase activation: ligand do nothing, increase number of receptors- have more receptors so there is more likelihood and chance of interaction with the ligand. Ex: using a big net vs a smaller net. Central grouping- brain and spinal cord (ex: like integration center)
