HSCI 301 Lecture Notes - Lecture 11: H2 Antagonist, Proton-Pump Inhibitor, Peptic Ulcer

• School: Drexel University
• Department: Health Sciences
• Course: HSCI 301
• Professor: William D' Andrea

Document Summary

Chapter 31 gi & antiemetic drugs: treating, peptic ulcers (open sores inside lining of esophagus, stomach, and upper small intestine/duodenal causes abdominal burning pain, causes: Increased hcl secretion from parietal cells: tumors (more rare) Inadequate mucosal defense: treatment, eradicate h. pylori, drugs, triple therapy prevpac: amoxicillin, clarithromyacin, reduce gastric acid secretion by h2 receptor antagonists. Lansoprazole (prevacid: pantoprazole (protonix, esomeprazole (nexium, cyto-protectant prostaglandin to reduce gastric acid secretion, prostaglandin is made by mucosa that inhibits secretion of gastric acid & stimulates cyto-protection by secreting mucus and bicarbonate to make mucus thicker. Irritable bowel syndrome (ibs)/ spastic colon: abdominal pain, discomfort, (cid:271)loati(cid:374)g, (cid:272)o(cid:374)stipatio(cid:374), or diarrhea : treatments: Ibs-d (diarrhea): analogs of opioid pain relievers but lacks analgesic effects: lomoil (diphenoxylate + atropine, loperamide (imodium a-d) Ibs-c (constipation: bisacodyl (dulcolax, senna (ssennosoids/ex-lax, lactulose (enulose, docusate sodium (colace, polyethylene glycol (peg) (miralax or go-lytely)