CAS NE 525 Lecture Notes - Lecture 7: Atg5, Dnm1L, Mitochondrion

• School: Boston University
• Department: Neuroscience
• Course: CAS NE 525
• Professor: Lucia Pastorino

Document Summary

Proteostasis in pd is disrupted and so the dysfunctional mitochondria are not degraded which leads to release of ros. A-synuclein aggregates which could be directly toxic or form protofibrils which then leads to neuronal death. Pink1 and lrrk2 mutations leads to inappropriate phosphorylation leading to neuronal death. Cytochrome c release can bind to procaspase 9, apoptosome leads to caspase 9, caspase 3, initiate apoptosis. Two proteins particularly important to control removal of malfunctioning mitochondria - parkin and pink1: mutations associated with recessive familial pd. Correct proteostasis guarentees a protein"s function to ultimately maintain cellular homeostasis. Parkin and pink 1 as crucial regulators of autophagy and mitophagy: physiological role: allow mitophagy to occur, if parkin and pink1 loose function: no more mitophagy. Loss of function and gain of toxic function in pd. E3 ligase regulates proteosomal degradation of proteins. Itself is tagged by ubiquitin (it is ubiquitinated) It is expressed particularly in cns (seen in northern blot analysis studies mrna.