NUSCTX 103 Lecture Notes - Lecture 11: Succinyl-Coa, Acetyl-Coa, Pyruvate Dehydrogenase
3 Dec 2020
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Document Summary
Metabolic compartments: nadh goes into mitochondria for etc, glycerophosphate shuttle, malate-aspartate shuttle. Net energy yield from aerobic metabolism of glucose (tca) tcac generated 2/3 of energy in the body: 38 atp or something made. Any carbon entering the cycle as acetyl-coa may result in net oxidation; any carbon that enters tcac via an anaplerotic pathway will not result in net oxidation, but must be used by some other routes. Example: aspartate, can become oxaloacetate, can get out other intermediates, so for example can become glutamate, glutamate can also be made, basically, amino acids can be made from the intermediates of the tca cycle. Thiamine deficiency: readily available in whole grain cereals, mostly in the outer layers of the grain, but is removed with milling and refining. Tca cycle: rapid improvement occurs with thiamine treatment, thiamine is an essential nutrient, decarboxylation of a-keto acids (pdh, akgdh and metabolism of bcaa"s, transketolation reactions (pentose phosphate pathway)
