NUSCTX 103 Lecture Notes - Lecture 15: Acetyl-Coa, Citric Acid Cycle, Protein Catabolism
3 Dec 2020
School
Department
Course
Professor
Document Summary
Ii. camp mediates effects of glucagon and epinephrine. General features of gng: liver and kidney, flux-generating step = substrate supply, substrates, amino acids metabolized to pyruvate or tca cycle intermediates, nadh, odd-chain fatty acids propionate tca cycle (succinyl-coa, lactate/alanine, nadh, glycerol, nadh. Two enzymes (pyruvate carboxylase and pepck) catalyze one by pass step in gng. Glucagon and epinephrine (via camp) reduce glycolysis and increase glycogenolysis. Factors that influence pyruvate carboxylase (needs mitochondria) (pyruvate to oaa: atp is required, acetyl coa is an allosteric activator, directing pyruvate into gng, (acetyl coa from b- oxidation is high in fasting) In mitochondria: oaa leaves the mitochondria using the malate, reverser of tca cycle. Malate has a transporter comes out, converts to oaa in cytosol. Pepck works, reverse up to glucose in the liver: pyruvate can become oaa during gng, pyruvate can become acetyl coa and goes through tca cycle, pdh complex.
