NUSCTX 103 Lecture Notes - Lecture 8: Acetyl-Coa, Pyruvate Dehydrogenase, Citric Acid Cycle

• School: Berkeley
• Department: Nutritional Sciences And Toxicology
• Course: NUSCTX 103
• Professor: Olzmann

Document Summary

Lec c: coordination of glycolysis with the tca cycle to meet energy needs. Study guide pyruvate translocase) (pdh &) tca : mitochondrial matrix: be able to describe why small changes in atp concentrations in cells can have profound effects on flux through glycolysis & the tca cycle. Flux is highest when high concentrations of substrate & low energy. *pdh btwn glycolysis & tca: know in what compartments glycolysis and the tca cycle occur and know how the key product of glycolysis moves from one compartment to another in order for these reactions to proceed. Glycolysis (& lactic acid fermentation) : cytosol ( pyruvate transported into mito matrix by: know in what compartments nadh & atp are produced from both glycolysis and the tca cycle. Glycolysis: make net 2 atp, 2 (x3) nadh > 8 atp (fermentation/lactate: use 2 nadh > - 6 atp) Pdh (pyruvate > acetyl coa): 2 nadh > 6 atp.