NUSCTX 103 Lecture Notes - Lecture 8: Keto Acid, Oxidative Phosphorylation, Citric Acid Cycle
6 Jan 2020
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Lec c: coordination of glycolysis with the tca cycle to meet energy needs. Study guide (part 2: be able to describe the role of ampk ( amp-activated protein kinase) in responding to energy status. Activated via amp & phosphorylation (active form: ampk + amp + p) Independent of insulin! (metformin mechanism to stimulate glucose uptake?) Stresses that activate ampk : low gluc or o2, metabolic poisons, exercise, ischemia (disruption of blood supply) Leptin : (more w/more wat) decreases food intake, increases energy expenditure & thermogenesis. Adiponectin: increases food (gluc) intake: know why thiamine is an essential nutrient, and the mechanism by which is performs its main function. Aka vit b1, micronutrient (can"t be synthesized by body! In whole grains) deficiency (beriberi)= ns & cv disorders, confusion, weakness, anorexia, loss of muscular functions. Used for decarboxylation of alpha keto acids (in pdh, alpha-kgdh, metabolism of. 10. know why thiamine is repeatedly phosphorylated and dephosphorylated.
