PUBH 1145 Lecture Notes - Lecture 2: Natural Killer Cell, Mucous Membrane, Sebaceous Gland
12 Sep 2020
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Document Summary
The body"s ability to resist infection disease: relies on distinguishing self from non-self. Antigen: foreign substance that the body recognizes as non-self, has antibodies receptor sites that are not recognizable as self. Present at birth and provides immediate, short-term protection. Intact skin: physical barrier to pathogen, produces sweat, tears, sebum, saliva to trap or kill pathogens. Mucous membranes: lines the body passages open to the exterior, produces mucus that traps foreign material. Phagocytosis: phagocytes (a type of wbc) can engulf and destroy pathogens, macrophages are primarily below the epidermis / mucous membranes / other tissues, neutrophils are primarily in the blood, but can enter sites of injury or infection. Complement: plasma proteins that can bind to bacteria, activation starts lytic cascade and attracts phagocytes. Natural killer cells: leukocyte that recognizes and kills virus-infected cells and some cancers, secrete lytic chemicals. Interferons: anti-viral cells resulting from viral infection, stimulates cells to resist infection.
