Pathology 2420A Lecture Notes - Lecture 12: Subarachnoid Hemorrhage, Amyotrophic Lateral Sclerosis, Upper Motor Neuron

• School: Western University
• Department: Pathology
• Course: Pathology 2420A
• Professor: Candace Gibson

Document Summary

Abscess - a localized area of infection filled with pus, and associated with tissue destruction and/or swelling. Amyloid - an extracellular protein substance; it is a waxy, amorphous, and eosinophilic material that may be stained with congo red: amyloid deposits are composed of straight, non-branching fibrils. Aphasia - loss of language function in which either understanding or expression of speech or both are affected: implies a cortical lesion in the dominant hemisphere. Apolipoprotein e - a protein involved in lipid transport in blood and brain. Three isoforms exist, apoe3 (most common), apoe4 (associated with an increased risk of alzheimer"s disease (ad)) and apoe2 (may confer protection against development of ad). Astrocyte - a class of glial cells; star-shaped cell which provides mechanical support and helps maintain the ionic composition within the central nervous system. Ataxia - incoordination, disruption of smooth precision of movements: cerebellar lesions are common causes.