Kinesiology 1070A/B Lecture Notes - Lecture 11: Meta-Analysis, Electroconvulsive Therapy, Reuptake

• School: Western University
• Department: Kinesiology
• Course: Kinesiology 1070A/B
• Professor: Scott Rollo

Document Summary

Study - initial severity and antidepressant benefits: a meta-analysis of data submitted to the food and drug administration. Meta-analysis of antidepressants have reported only modest benefits over placebo treatments. The efficacy of antidepressants may also depend on severity of depression. To establish relationship of severity and antidepressant efficacy using relevant dataset of published and unpublished clinical trials. Collect all studies, look at effectiveness of drugs and compare them to placebo, and also consider severity. Obtained data and clinical trials submitted to us food and drug administration for licensing for which full datasets were available. Meta analytic techniques were used to assess effects of initial severity on improvement scores for drug and placebo groups and on drug-placebo. Mean improvements was 9. 60 points in hamilton rating scale of. Depression and 7. 8 in placebo groups, a mean drug-placebo difference of 1. 80 on hrsd improvement. Fails to meet 3-point drug criteria for clinical significance. Standardized mean difference for drug groups was 1. 24 and placebo.