Kinesiology 1070A/B Lecture Notes - Lecture 11: Escitalopram, Citalopram, Antidepressant
27 Sep 2018
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Stem from how they affect certain brain circuits and neurotransmitters (pass along signals no multiple nerve cells) Re-uptake inhibitors prevent neurotransmitters being absorbed into the nerve cells of the brain. Allows the neurotransmitters to stay in the synapse longer. Levels of neurotransmitters higher= improve communication between nerve cells (strengthen circuits >regulate mood) Canada is the third largest user of antidepressants (under australia and iceland) Case study: initial severity and antidepressant bene ts= a meta analysis of data. Submitted to the food and drug administration (kersch et al) The ef cacy of the antidepressants also depend on the severity. Placebo used instead of clinical treatment (psychological theory-based on belief) Establish the relation between severity and anti-depressant ef cacy. Obtained data from published clinical trials (from the fda) Meta analytic techniques to asses linear and quadratic effects of initial severity on improvement scores for: Curve of the line of best t= quadratic effects. Used the hamilton rating scale of depression (9. 6 pts)
