Biochemistry 2288A Lecture Notes - Lecture 22: Gene Expression, Human Genome

• School: Western University
• Department: Biochemistry
• Course: Biochemistry 2288A
• Professor: Chris Brandl

Document Summary

Increase ability to obtain and use biochemical information provided in different formats: understand mechanisms of info flow in the cell, think critically about why biochemical mechanisms occur as they do, consider how structure relates to function. Resources: textbook and course notes are all testable, textbook is the primary resource -> use glossary, learning modules on owl. In any cell type, less than 10 000 are expressed: human genome encodes about 21 000 protein encoding genes, genes expressed at different levels, expression of the correct genes is essential for growth and differentiation. Different cell types (tissues) express different genes: ex. liver and brain express different genes. Significance of gene expression: most diseases are due to altered expression of 1 or more genes, by therapeutically manipulating gene expression, we have potential to prevent or reverse disease. At how many steps can gene expression be regulated in a eukaryotic cell: more than 8 steps, 1.