Biochemistry 2280A Lecture Notes - Lecture 17: Acetyl Group, Pyruvate Dehydrogenase, Citric Acid

• School: Western University
• Department: Biochemistry
• Course: Biochemistry 2280A
• Professor: Chris Brandl

Document Summary

Biochem lecture 17 acetyl coa 1: the citric acid cycle. Identify the different metabolic fates of pyruvate, and how these pathways are related. State the net reactions for the conversion of pyruvate to acetyle- coa and co2, and for the citric acid cycle (including stoichiometries) State the metabolic cirumstances under which oxidation of pyruvate and the citric acid cycle are favoured, without memorizing individual regulators. Many small pores that allow small molecules (<5000 da) to cross. Prevents ions and polar molecules from crossing, unless a special pathways exists; folded to form cristae. The space enclosed by the inner mitochondrial membrane. Pyruvate oxidation occurs in two stages: decarboxylation of pyruvate to form acetyl- coenzyme a (acetyl-coa, oxidation of the acetyl of acetyl-coa in the citric acid cycle. A carrier molecule; thiol (-sh group) is modified. Pyruvate dehydrogenase complex: 3 different enzymes in multiple. Acetyl- coa and nadh are competitive inhibitors copies; 60 polypeptide chains in all.