Biochemistry 2280A Lecture Notes - Lecture 10: Hans Adolf Krebs, Nicotinamide, Competitive Inhibition
15 Oct 2017
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By the end of this topic, you should be able to: describe the structure of the mitochondrion. Glycolysis takes place in the cytoplasm, producing pyruvate. We have already seen that, under anaerobic conditions, pyruvate can be fermented to lactate or ethanol. Pyruvate can also be used to make glucose when necessary. In this topic we will see a third metabolic fate of pyruvate. Under aerobic conditions, pyruvate produced by glycolysis is transported into mitochondria, where it is oxidized to form co2. The mitochondrion is an organelle with two membranes. The outer membrane has many pores embedded in it (fig 11-24, p. 372), and is freely permeable to most solutes of low molecular weight (up to about 5000 da). The inner membrane is impermeable to ions and charged molecules, which can only cross it if a special path is made. The inner membrane is folded to form cristae, greatly increasing its surface area.
