Biochemistry 2280A Lecture Notes - Lecture 10: Decarboxylation, Pyruvate Dehydrogenase Complex, Thioester

• School: Western University
• Department: Biochemistry
• Course: Biochemistry 2280A
• Professor: Boffa/ Mc Lauchlin/ Brandl

Document Summary

Topic 10: acetyl-coa part 1: the citric acid cycle. Identify the different metabolic fates of pyruvate, and how these pathways are related. State the net reactions for the conversion of pyruvate to acetyl-coa and co2, and for the citric acid cycle (including stoichiometries) State circumstances under which oxidation of pyruvate and the citric acid cycle are favoured or disfavoured, without memorizing individual regulators. Many b ig multi-protein pores embedded in it. F olded to form cris tae ( s a: s a(inner membrane) > s a (outermembrane) F reely permeable to most s olutes of low molecular weight (up to ~ 5000 daltons ) Matrix s pace enclos ed by the inner membrane. Mitochondrial genome e ncode s ome s ubunits of the complexes involved in oxidative phos phorylation & r na molecules required for trans lation of thes e s ubunits. Respiration = c onvert pyruvate + o 2 c o 2 + h 2o.