PSL301H1 Lecture Notes - Lecture 31: Metabolic Acidosis, Respiratory Acidosis, Methionine
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Ph = -log[h+] = the amount of h+ Where does h+ come from: fatty acids and a. a (diet, production of metabolic acids from oxidation (metabolism) Fatty acids, acid from protein, protein contains sulfur-containing amino acids cysteine and methionine metabolize into sulphuric acid (h2so4) Average american diet generates 70 mmol of h+/day. However, if 70 mmol/l of h+ were added to our body . How our body prevent acidosis after we have a big meal. Big meal: input of fatty acids, amino acids, metabolic acids, ect. (h+) Our body buffers the incoming h+ with hco3. Phosphates and ammonia in urine: h+ + b- hb, buffer decrease the [h+] in solution. In ecf: bicarbonate: hco3, monohydrogen phosphate: H+ + hco3: increase h+ would decrease the amount of hco3. This relation can be described using henderson hasselbalch equation . Ph is related to the ratio of bicarbonate and pco2: the lower the bicarbonate. Respiratory acidosis increase in bicarbonate concentration.
