BIO230H1 Lecture Notes - Lecture 4: Purine Metabolism, Riboswitch, Purine
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BIO230H1 Full Course Notes
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Eukaryotic gene regulation: eukaryotic transcriptional activation, eukaryotic transcriptional repression. Transcription initiation rna polymerase binds to dna. In both pro/eukaryotes there can be a premature termination of transcription called. Rna adopts a structure that interferes with rna polymerase. The base pairs are interacting with one another forming 3-d structures. Regulatory proteins can bind to rna and interfere with attenuation. Prokaryotes, plants, and fungi also use riboswitches to regulate gene expression. Riboswitches: a short rna sequence that changes conformation when bound by a small molecule. Different size of ring (py 6 atom ring, pu 9 atom ring) Rna polymerase transcribing genes for purine biosynthesis. Rna strand begins to fold on itself and the bases associate. Transcription of purine biosynthetic genes is on. Transcription of purine biosynthetic genes is off. Dna is transcribed into rna by rna polymerase. In eukaryotes there are multiple types of rna (that aren"t in pro) snrnas snornas. Also have 3 different types of rna polymerase (i, ii, iii)
