BIO230H1 Lecture Notes - Lecture 8: Basal Lamina, Tight Junction, Cell Adhesion
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Bio230 s2 lec2 cell adhesion & tissue morphogenesis oct 30. Topics: formation of large and stable organisms from small fragile cells, establishment of polarity of the cell, tissue morphogenesis. Cells directly connected with minimal extracellular matrix beneath. Mechanical stresses are transmitted from cell to cell by cytoskeletal filaments anchored to cell-matrix and cell-cell adhesion sites. > 60% of our body cell types. Epithelial cells would face the lumen, or the surface. Cells dispersed with extracellular matrix providing overall structure. Extracellular matrix directly bears mechanical stresses of tension and compression. Face inside -> in the middle: epithelial cells definitely have the junctions that are in the order (from apical side to basal side, occluding junctions most apical side, tight junction. Seals gap between epithelial cells to block the stuff from going through. Of tight junctions are all around regions between the 2 cells, the sealing strands would be formed.
