BIO130H1 Lecture Notes - Lecture 16: Tight Junction, Atp Synthase, Cystic Fibrosis
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BIO130H1 Full Course Notes
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Na+/k+ pump: glucose transport, atpases, membrane potential and nerves. Cystic fibrosis and how the transporters relate to lecture. Information on this not on exam - see weboption. One protein changes, and it creates a vast change in the body. Pumping cycle of the na+/k+ pump - important (shown below) Atp is bound to the pump, 3 na+ bind an open cytosolic pocket (against gradient) Here, it is in an e1 conformation - means that it is open to the cytosolic slide. Later the e2 conformation will be encountered - here, it is open to the extracellular space: pocket closes preventing na+ escape (occluded, atp hydrolysis occurs, pump phosphorylated, release of adp cause a conformational change to e2. In e2 the binding pocket is exposed on the extracellular side, 3 na+ exit. 4: 2 k+ bind while in e2 conformation, the pocket closes, preventing k+ release.
