BIO130H1 Lecture Notes - Lecture 16: Resting Potential, Antiporter, Chlorine
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BIO130H1 Full Course Notes
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Bio130 lecture 16 pumps and transport. Cystic fibrosis is a recessive genetic disease that causes progressive disability. Difficulty breathing is most common, which results from frequent lung infections. The cftr gene is often mutated: the cftr protein is required to regulate the components of sweat, digestive juices, and mucus. Cftr is an abc transporter-class transporter protein that transports chloride and thiocyanate. Pumping cycle of na+/k+ pump: atp is bound to the pump, 3 na+ bind an open cytosolic pocket, the pocket closes preventing na+ escape, atp hydrolysis occurs, pump phosphorylated, release of adp cause a conformational change to e2. In e2 the binding pocket is exposed on the extracellular side, 3na+ exit. 4: 2 k+ bind, the pocket closes preventing k+ release, the pump is dephosphorylated, atp binds the pump returning it to the e1 state and k+ is released into the. Work together to transfer glucose from the intestine to the blood stream.
