BIO130H1 Lecture Notes - Lecture 11: Tata Box, Transcription Factor Ii B, Transcription Factor Ii D

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10 Feb 2017

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Rnap"s are complex structures with many subunits: some subunits are common to all three rnap"s, some subunits resemble the subunits of dna. Eukaryotic vs. bacterial rna polymerases: eukaryotic rna polymerases require proteins to help position them at the promoter, called sigma factors. 2)these factors fulfill a similar role to the promoters of the bacterial rna polymerases. 3)eukaryotic rna polymerases need to deal with everything. Tata box: the sequence tata highly conserved, found 25-36 bp upstream from start site for transcription. Binding of tbp along with rest of tfiid (includes tafs) Mobilizes the binding of tfiib complex adjacent to tata box. Rnap can now bind in correct orientation at start site. Steps in the initiation of transcription: a subunit binds to the tata box promoter in the minor groove, bending and distorting the dna. 2)this attracts other transcription factors, which help to orient and bind rna to the dna.

Related Questions

The TATA-binding protein (TBP) binds to the TATA box sequence in eukaryotic promoters. What is its function in transcriptional initiation?

It blocks access of RNA polymerase to the promoter, until removed by general transcription factors.

It is the subunit of prokaryotic RNA polymerase that is required to recognize promoters.

It modifies histones so nucleosomes can be removed from DNA for transcription.

It bends and partly unwinds DNA at a promoter.

The genetic code is said to be âdegenerateâ because

there are more codons than amino acids.

there are more amino acids than codons.

different organisms use different codons to encode the same amino acid.

some codons specify more than one amino acid.

Three general mechanisms appear to be responsible for the conversion of proto-oncogenes to oncogenes

overexpression, point mutations, deletions

inversions, translocations, methylation

familial, sporatic, phosphorylation

None of the above account for the conversion of proto-oncogenes into oncogenes

Transcriptional control of genes that acts by regulating the continuation of transcription is called

induction

attenuation

antitermination

negative inducible control

The genetic code is fairly consistent among all organisms. The term used to describe this consistency is

The F, G, and H loci are linked in the order written. There are 30 cM between F and G and 30 cM between G and H. If a plant Ff Gg Hh is testcrossed, what proportion of the progeny will be ff gg hh, assuming no interference?

DNA synthesis is always from 5â to 3â because

replication must be continuous

the strands are antiparallel

primers lack 3â to 5â exonuclease activity

In the ZZ-ZW sex-determination system, if an AaBb female was crossed to an individual of genotype Aa Bb, what is the probability of a female offspring with the two dominant traits given by alleles A and B? Assume A and B are dominant alleles.