BIOC65H3 Lecture Notes - Lecture 5: Anaphylaxis, Pheniramine, Mast Cell
14 Dec 2017
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Bioc65 lecture 5: inflammation continued: cortisol, the sugar- Histamine = amine, histamine receptors (h1 is the most important) Macroscopic symptoms: reddening, swelling, itch and pain. Mast cells release the most histamine disease that has too many mast cells = mastocytosis, get mast cell degranulation very readily have to be on mast cell stabilizers or anti-histamines all the time. Niacin = prostaglandins up prostaglandins, can bypass histamine cascade; prostaglandins give elevated temperature and gives the pain symptom. Vasodilation somewhere, you"ll get vasoconstriction anaphylactic shock is lethal histamine response going crazy. Arachidonic acid is metabolized to produce inflammatory mediators. Many current anti- inflammatory and pain medicines are inhibiting some portion of the arachidonic acid pathways. Cyclooxygenases: cox1 is always on, cox2 is inducible; cox 1 always produces some prostaglandin. Non-steroidal anti-inflammatory drugs (aspirin, ibuprofen) target the coxs; celebrex or coxibs are inhibitors of cox) can lead to heart attacks. Shouldn"t be on anti-inflammatory response all the time.
